Genetic Mutations In Songbird

Genetic Mutations In Songbird

New studies have shown that there is a genetic bend in the small species of the songbirds in parallel with their ability to carry tunes in their mind. A new study in the National Academy of Sciences claimed that zebra finches or some other kind of songbirds contain a low-density lipoprotein receptor (LDLR) which is a gene that is found to be surprisingly different from another kind of vertebrates.

Genetic Mutations In Songbird

The primary function of the lipoprotein receptor is the cellular uptake of the cholesterol, which is bound to LDL or, in other words, we can say bad cholesterol, which was earlier thought to be present in the vertebrates. The scientists of the OHSU found that in songbirds, the main, or we can say the binding domain for the functionality of the primary receptor, was lagging.

Genetic Mutations In Songbird

The mutations like these serve as a leading cause for high cholesterol and serve in addition to cardiovascular diseases. To be clear, it was a surprise for the scientists to know that the causes of cardiovascular diseases have not been seen in songbirds as the songbirds carry most of their cholesterol in HDL or High-Density Lipoprotein or other words it is also known as good cholesterol. Hence they are surprised to see the effect of this cholesterol on this species.

Senior author Claudio Mello, a professor of behavioral neuroscience at the school of medicine situated at Oregon Science University, claimed that these songbirds have adapted to the conditions and mutations very well so that their LDLR changed affect much. Thus, they have developed a healthy cholesterol profile.

He also stated that it seems like they have some mutations to protect from different types of cardiovascular diseases. He said that his team is working relentlessly to find the facts, which can be a large step towards studying cardiovascular diseases and their remedies.

The songbirds can act as a model for the study of protection and improve the quality of treatment by understanding the biological abilities of these birds that can, in turn, help in the growth of the health industry.

These, not so natural and unsuspecting nature of the mutation in the songbirds can impact the viral entry, gene therapies, or cellular transport systems, making the study in medicine and sciences vast and serve for the survival of mankind.

LDLR is also known as the main receptor for the protein in the (VSV G) virus or the vesicular stomatitis virus and can also be used by pseudotype or coating lentiviral vectors the manipulation of genes in the animals and can also be beneficial in the gene therapy for the humans.

A low susceptibility of the finches in lentiviruses which is also a family group of HIV, pseudotype with a VSV G is explained due to the lack of functional domain in LDLR. This genetic discovery can lead to a broader study of the high quality of genome, which is sequenced in many animals. It was also part of the initiative with was funded by the OHSU and many other institutes.

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